Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | PLK1 | P53350 | 10/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7242637 | 0.94 | FYN (0.59) | FYNKDRPLK1IGF1RAURKA | |
| SCHEMBL7234789 | 0.89 | KDR (0.64) | FYNKDRPLK1IGF1RJAK2 | |
| Hydrochloric Acid SCHEMBL7240520 | 0.88 | FYN (0.56) | FYNKDRPLK1IGF1RAURKA | |
| SCHEMBL7240926 | 0.88 | FYN (0.57) | FYNKDRPLK1IGF1RIKBKB | |
| Hydrochloric Acid SCHEMBL7240228 | 0.88 | FYN (0.65) | FYNKDRPLK1IGF1RPTK2 | |
| SCHEMBL7232580 | 0.86 | KDR (0.63) | FYNKDRPLK1IGF1RAURKA | |
| SCHEMBL7231388 | 0.86 | FYN (0.61) | FYNKDRPLK1IGF1RIKBKB | |
| Hydrochloric Acid SCHEMBL7232574 | 0.85 | PLK1 (0.64) | FYNKDRPLK1IGF1RPTK2 | |
| SCHEMBL7001153 | 0.85 | FYN (0.56) | FYNKDRPLK1IGF1RIKBKB | |
| SCHEMBL7237418 | 0.85 | FYN (0.65) | FYNKDRPLK1IGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |