Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 2/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | STK17B | O94768 | 2/20 | 0.47 |
| ▸ | STK10 | O94804 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7244546 | 0.84 | EGFR (0.45) | EGFRERBB2ERBB4KITSRC | |
| SCHEMBL7241984 | 0.83 | AURKA (0.49) | EGFRERBB2ERBB4SRCKDR | |
| SCHEMBL7117656 | 0.81 | EGFR (0.48) | EGFRERBB2ERBB4KITSRC | |
| SCHEMBL7127851 | 0.81 | EGFR (0.47) | EGFRERBB2ERBB4KITSRC | |
| SCHEMBL7239476 | 0.81 | EGFR (0.57) | EGFRERBB2ERBB4SRCKDR | |
| SCHEMBL4187414 | 0.77 | EGFR (0.68) | EGFRERBB2ERBB4KITSRC | |
| SCHEMBL7240170 | 0.76 | EGFR (0.60) | EGFRERBB2ERBB4KITSRC | |
| SCHEMBL4185100 | 0.75 | EGFR (0.68) | EGFRERBB2ERBB4KITSRC | |
| SCHEMBL7242500 | 0.75 | EGFR (0.51) | EGFRERBB2ERBB4KITSRC | |
| SCHEMBL7121714 | 0.75 | AURKB (0.43) | EGFRERBB2ERBB4KITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |