Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.76 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.76 |
| ▸ | JAK3 | P52333 | 3/20 | 0.76 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238659 | 0.92 | EGFR (0.76) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7244619 | 0.91 | EGFR (0.77) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7235040 | 0.90 | EGFR (0.76) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7241722 | 0.89 | EGFR (0.76) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7239555 | 0.89 | EGFR (0.64) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7243116 | 0.89 | EGFR (0.71) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7239777 | 0.88 | EGFR (0.78) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7239782 | 0.88 | EGFR (0.78) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7239962 | 0.87 | EGFR (0.68) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7235009 | 0.86 | EGFR (0.73) | EGFRERBB2ERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |