Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 4/20 | 0.39 |
| ▸ | PLK1 | P53350 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230375 | 0.88 | FYN (0.51) | FYNKDRIKBKBPDGFRBIGF1R | |
| SCHEMBL7241210 | 0.87 | FYN (0.49) | FYNKDRIKBKBPDGFRBIGF1R | |
| SCHEMBL7240933 | 0.85 | FYN (0.52) | FYNKDRRIPK2NOD2IKBKB | |
| SCHEMBL7240926 | 0.80 | FYN (0.57) | FYNKDRRIPK2NOD2IKBKB | |
| SCHEMBL7234420 | 0.80 | IKBKB (0.48) | FYNKDRIKBKBIGF1RPLK1 | |
| SCHEMBL7002121 | 0.77 | FYN (0.66) | FYNKDRIKBKBIGF1RPLK1 | |
| Hydrochloric Acid SCHEMBL7240520 | 0.75 | FYN (0.56) | FYNKDRRIPK2NOD2IKBKB | |
| SCHEMBL7237418 | 0.73 | FYN (0.65) | FYNKDRIKBKBPDGFRBIGF1R | |
| SCHEMBL7230505 | 0.73 | FYN (0.49) | FYNKDRIKBKBPDGFRBIGF1R | |
| SCHEMBL7234843 | 0.72 | FYN (0.58) | FYNKDRIKBKBPDGFRBIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |