SCHEMBL7243772

SCHEMBL7243772

COC(=O)C(N)CNC(=O)OCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 1/20 0.55
SLC1A1 P43005 1/20 0.55
LMNA P02545 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
HTT P42858 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
SYK P43405 1/20 0.50
CA12 O43570 2/20 0.49
CA1 P00915 2/20 0.49
CA2 P00918 2/20 0.49
CA9 Q16790 2/20 0.49
DPP8 Q6V1X1 1/20 0.48
DPP7 Q9UHL4 1/20 0.48
LTA4H P09960 1/20 0.48
ALDH1A1 P00352 2/20 0.48
TRPM8 Q7Z2W7 1/20 0.48
ALOX15 P16050 1/20 0.48
PLAU P00749 1/20 0.48
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14335621 1.00 SLC1A3 (0.55) SLC1A3SLC1A1LMNASMN1; SMN2HTT
Hydrochloric Acid SCHEMBL7243767 0.99 SLC1A3 (0.54) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL29398484 0.91 SLC1A3 (0.58) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL10705141 0.88 SLC1A1 (0.65) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL542279 0.88 SLC1A1 (0.65) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL7375139 0.88 SLC1A1 (0.65) SLC1A3SLC1A1LMNASMN1; SMN2HTT
Hydrochloric Acid SCHEMBL7355918 0.87 SLC1A1 (0.64) SLC1A3SLC1A1LMNASMN1; SMN2HTT
Hydrochloric Acid SCHEMBL383365 0.87 SLC1A1 (0.64) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL14381151 0.87 SLC1A3 (0.56) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL6500075 0.86 SYK (0.61) SLC1A3SLC1A1LMNASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012175514-A1 PYRIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2012-12-27 WO disclosed
US-6509337-B1 A method of treating a mammalian disease condition mediated by metalloproteinase activity which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound as defined in claim 1 or a pharmaceutically PFIZER INC. 2003-01-21 US disclosed
EP-0821671-B1 ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS PFIZER (US) 2000-12-27 EP disclosed
US-5861510-A Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors PFIZER INC (US) 1999-01-19 US disclosed
EP-0821671-A1 ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS PFIZER INC. (US) 1998-02-04 EP disclosed
WO-1996033172-A1 ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS PFIZER INC. (US) 1996-10-24 WO disclosed