Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.55 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7239881 | 0.91 | SRD5A2 (0.63) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL7246467 | 0.84 | KDM4E (0.73) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL7246655 | 0.83 | KDM4E (0.71) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL630515 | 0.81 | SRD5A2 (1.00) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL9816433 | 0.77 | KDM4E (0.73) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL28718294 | 0.77 | CYP2A6 (0.44) | PDGFRBPDGFRAMAPTHDAC1 | |
| SCHEMBL4311301 | 0.76 | KDM4E (0.71) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL7241630 | 0.76 | KDM4E (0.59) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL13345030 | 0.75 | KDM4E (0.62) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 | |
| SCHEMBL6542663 | 0.75 | KDM4E (0.69) | KDM4EHPGDSRD5A2HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630496-B1 | Antiinflammatory agents inhibit phospholipase 2, affecting both protaglandin and leukotriene production; indoles substituted in 2 position by 2,4-dioxo-thiazol-3-yl methylidene | GENETICS INSTITUTE LLC | 2003-10-07 | — | — | US | disclosed |