Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 19/20 | 0.88 |
| ▸ | EDNRA | P25101 | 19/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252235 | 0.95 | EDNRB (0.89) | EDNRBEDNRAKMT2A | |
| SCHEMBL7246598 | 0.95 | EDNRB (0.80) | EDNRBEDNRA | |
| SCHEMBL7246781 | 0.94 | EDNRB (0.86) | EDNRBEDNRA | |
| SCHEMBL7252229 | 0.94 | EDNRB (1.00) | EDNRBEDNRAKMT2A | |
| SCHEMBL7253898 | 0.93 | EDNRB (0.86) | EDNRBEDNRAKMT2A | |
| SCHEMBL7248173 | 0.92 | EDNRB (0.82) | EDNRBEDNRAKMT2A | |
| SCHEMBL7247318 | 0.92 | EDNRB (0.83) | EDNRBEDNRAKMT2A | |
| SCHEMBL7252953 | 0.91 | EDNRB (0.82) | EDNRBEDNRAKMT2A | |
| SCHEMBL7252244 | 0.90 | EDNRB (0.87) | EDNRBEDNRA | |
| SCHEMBL7252367 | 0.90 | EDNRB (1.00) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670367-B1 | Vasodilator; hypertension; surprisingly show antagonistic action on the neurokinin receptor; 2-(4-Methoxy-6-methyl-2-pyrimidinyloxy)-3-(2-(3,4- dimethoxyphenyl)ethoxy)-3,3-diphenylpropionic Acid | ABBOTT GMBH & CO., KG (DE) | 2003-12-30 | — | — | US | disclosed |