Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.42 |
| ▸ | HRH2 | P25021 | 10/20 | 0.38 |
| ▸ | HRH1 | P35367 | 10/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248411 | 0.85 | IDH1 (0.35) | HRH2HRH1 | |
| SCHEMBL7248335 | 0.84 | HRH3 (0.39) | HRH2HRH1HRH3ALOX15HSD17B10 | |
| SCHEMBL6095515 | 0.84 | KCNA5 (0.45) | KCNA5HRH2HRH1HRH3ALOX15 | |
| SCHEMBL7246185 | 0.81 | KCNA5 (0.59) | KCNA5HRH2HRH1HRH3MMP2 | |
| SCHEMBL7250880 | 0.80 | HRH2 (0.46) | KCNA5HRH2HRH1HRH3MMP2 | |
| SCHEMBL7245961 | 0.80 | HRH2 (0.45) | KCNA5HRH2HRH1HRH3MMP2 | |
| SCHEMBL7252155 | 0.79 | KCNA5 (0.48) | KCNA5HRH2HRH1HRH3 | |
| SCHEMBL7243245 | 0.79 | HRH2 (0.44) | KCNA5HRH2HRH1HRH3MMP2 | |
| SCHEMBL7243596 | 0.78 | KCNA5 (0.45) | KCNA5HRH2HRH1HRH3 | |
| SCHEMBL7252363 | 0.78 | HRH2 (0.48) | KCNA5HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559162-B2 | Electrophysiological activity | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | disclosed |
| EP-1244631-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047893-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |