Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.65 |
| ▸ | PDE6C | P51160 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447206 | 0.91 | PDE5A (0.67) | PDE5APDE6C | |
| SCHEMBL6441913 | 0.86 | PDE5A (0.69) | PDE5APDE6C | |
| SCHEMBL6446885 | 0.86 | PDE5A (0.70) | PDE5APDE6CALDH1A1 | |
| SCHEMBL6447170 | 0.86 | PDE5A (0.78) | PDE5APDE6C | |
| SCHEMBL7239340 | 0.85 | PDE5A (0.68) | PDE5APDE6CALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7248338 | 0.85 | PDE5A (0.61) | PDE5APDE6C | |
| Hydrochloric Acid SCHEMBL6443324 | 0.84 | PDE5A (0.65) | PDE5APDE6C | |
| SCHEMBL6441959 | 0.83 | PDE5A (0.69) | PDE5APDE6C | |
| SCHEMBL6443099 | 0.82 | PDE5A (0.67) | PDE5APDE6C | |
| SCHEMBL7244120 | 0.81 | PDE5A (0.57) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670366-B1 | Cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors; impotence; pyrazolo(4,3-d)pyrimidin-7-ones | PFIZER INC | 2003-12-30 | — | — | US | disclosed |
| EP-0995750-A1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |