SCHEMBL7246722

SCHEMBL7246722

NC1Cc2cc(Br)ccc2N(Cc2c[nH]cn2)C1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 12/20 0.33
FNTB P49356 12/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7244896 0.99 FNTA (0.33) FNTAFNTB
SCHEMBL7241421 0.81 FNTA (0.39) FNTAFNTB
SCHEMBL7252908 0.80 FNTA (0.37) FNTAFNTB
SCHEMBL3529035 0.79 HDAC1 (0.40)
SCHEMBL7248085 0.78 BCHE (0.39) FNTAFNTB
SCHEMBL3531066 0.77 HDAC1 (0.46)
SCHEMBL3499392 0.77 FNTA (0.51) FNTAFNTB
SCHEMBL3501511 0.75 FNTA (0.53) FNTAFNTB
SCHEMBL3499861 0.74 FNTA (0.51) FNTAFNTB
SCHEMBL3502958 0.73 FNTA (0.53) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6602883-B1 Inhibitors of farnesyl protein transferase BRISTOL-MYERS SQUIBB COMPANY 2003-08-05 US disclosed
US-6387926-B1 ANTICANCER AGENTS BRISTOL-MYERS SQUIBB COMPANY 2002-05-14 US disclosed
EP-0994856-A4 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE BRISTOL MYERS SQUIBB CO (US) 2000-12-06 EP disclosed
EP-0994856-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE BRISTOL-MYERS SQUIBB COMPANY (US) 2000-04-26 EP disclosed
WO-1999001434-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE BRISTOL-MYERS SQUIBB COMPANY (US) 1999-01-14 WO disclosed