Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 13/20 | 0.57 |
| ▸ | RBPJ | Q06330 | 4/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | NOTCH3 | Q9UM47 | 9/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | NOTCH2 | Q04721 | 1/20 | 0.36 |
| ▸ | NOTCH4 | Q99466 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7247076 | 0.90 | NOTCH1 (0.59) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7514440 | 0.88 | NOTCH1 (0.56) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7247403 | 0.86 | NOTCH1 (0.53) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3289624 | 0.80 | NOTCH1 (0.69) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3289785 | 0.79 | NOTCH1 (0.63) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287228 | 0.79 | NOTCH1 (0.63) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3289599 | 0.78 | NOTCH1 (0.67) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5948015 | 0.78 | NOTCH1 (0.53) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287904 | 0.78 | NOTCH1 (0.53) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3286623 | 0.78 | NOTCH1 (0.66) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020055501-A1 | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-05-09 | — | — | US | claimed |
| US-6525044-B2 | Treatment of neurological disorders related to beta -amyloid production such as Alzheimer's disease and Down's Syndrome. | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-25 | — | — | US | disclosed |
| US-20020055501-A1 | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055501-A1 | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production | APP, APH1A, APH1B | NOTCH1 383/4885RBPJ 2054/4885PSEN1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.