Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.49 |
| ▸ | RAF1 | P04049 | 5/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234414 | 0.92 | SRC (0.57) | SRCFYNMAP2K1RAF1MAPK3 | |
| SCHEMBL3233818 | 0.91 | SRC (0.66) | SRCFYNMAP2K1RAF1MAPK3 | |
| SCHEMBL3224239 | 0.87 | SRC (0.62) | SRCFYNMAP2K1RAF1 | |
| SCHEMBL3229392 | 0.85 | MAP2K1 (0.69) | SRCFYNMAP2K1RAF1MAPK3 | |
| SCHEMBL3223377 | 0.82 | SRC (0.69) | SRCFYNMAP2K1 | |
| SCHEMBL3231525 | 0.81 | SRC (0.70) | SRCFYNMAP2K1RAF1 | |
| SCHEMBL7673290 | 0.81 | SRC (0.64) | SRCFYNMAP2K1RAF1MAPK3 | |
| SCHEMBL3224684 | 0.81 | SRC (0.57) | SRCFYNMAP2K1 | |
| SCHEMBL3212451 | 0.80 | SRC (0.64) | SRCFYNMAP2K1 | |
| SCHEMBL3228485 | 0.80 | SRC (0.60) | SRCFYNMAP2K1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521618-B2 | Antineoplastic agents, agents for treatment of osteoporosis and polycystic kidney disease | WYETH | 2003-02-18 | — | — | US | disclosed |