Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.36 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245539 | 0.94 | SLC6A4 (0.43) | MCHR1HRH3SLC6A4KMT2AKCNH2 | |
| SCHEMBL6094346 | 0.88 | MCHR1 (0.46) | MCHR1HRH3SLC6A4KCNH2FKBP1A | |
| SCHEMBL7245376 | 0.88 | HRH3 (0.40) | HRH3SLC6A4SIGMAR1 | |
| SCHEMBL7242841 | 0.85 | SLC6A4 (0.39) | MCHR1HRH3SLC6A4 | |
| SCHEMBL7242632 | 0.84 | SLC6A4 (0.40) | HRH3SLC6A4 | |
| SCHEMBL7242668 | 0.83 | POLB (0.40) | MCHR1HRH3SLC6A4 | |
| SCHEMBL7246406 | 0.83 | HRH3 (0.37) | HRH3SLC6A4KMT2AFKBP1AFKBP4 | |
| SCHEMBL5965830 | 0.83 | MCHR1 (0.42) | MCHR1HRH3SLC6A4FKBP1AFKBP4 | |
| SCHEMBL7028310 | 0.83 | MCHR1 (0.43) | MCHR1HRH3SLC6A4FKBP1AFKBP4 | |
| SCHEMBL7244465 | 0.82 | HRH3 (0.37) | HRH3SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559162-B2 | Electrophysiological activity | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | disclosed |
| EP-1244631-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047893-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |