Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10267529 | 0.88 | PDE4C (0.64) | PDE4CCYP1A1CYP1B1TERTTLR8 | |
| SCHEMBL722554 | 0.83 | KDM4E (0.44) | PDE4CCYP1A1CYP1B1TERTADORA2A | |
| SCHEMBL725307 | 0.80 | PDE4C (0.54) | PDE4CPRKCQBRD4MAP3K11LRRK2 | |
| SCHEMBL16817173 | 0.75 | PDE4D (0.41) | PDE4CADORA2AJAK2JAK1TYK2 | |
| SCHEMBL721356 | 0.74 | KDM4E (0.42) | CYP1A1CYP1B1TERTAMY1A | |
| SCHEMBL723994 | 0.73 | PRKCQ (0.43) | PRKCQBRD4JAK2JAK3 | |
| SCHEMBL724878 | 0.73 | LRRK2 (0.47) | PDE4CCYP1A1CYP1B1PRKDCBRD4 | |
| SCHEMBL723240 | 0.73 | PDE4C (0.45) | PDE4CJAK2JAK1TYK2JAK3 | |
| SCHEMBL724620 | 0.72 | PDE4A (0.51) | PDE4CCYP1A1CYP1B1TERTADORA2A | |
| SCHEMBL724279 | 0.72 | CCNT1 (0.43) | PDE4CAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |