Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 12/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786455 | 0.88 | ACE (0.52) | ACEACE2CPT2CPT1AALDH1A1 | |
| SCHEMBL6786452 | 0.88 | ACE (0.52) | ACEACE2CPT2CPT1AALDH1A1 | |
| SCHEMBL6789072 | 0.78 | ACE (0.55) | ACEACE2CPT2CPT1AALDH1A1 | |
| SCHEMBL6789083 | 0.78 | ACE (0.55) | ACEACE2CPT2CPT1AALDH1A1 | |
| SCHEMBL2082602 | 0.76 | ACE (0.52) | ACEACE2CPT2CPT1AALDH1A1 | |
| SCHEMBL6794177 | 0.74 | KLK5 (0.50) | ACECPT2CPT1A | |
| SCHEMBL6794184 | 0.74 | KLK5 (0.50) | ACECPT2CPT1A | |
| Trifluoroacetic Acid SCHEMBL6789947 | 0.72 | ACE (0.52) | ACEACE2LTA4H | |
| SCHEMBL13071859 | 0.71 | DPP4 (0.48) | ACECPT2CPT1ACHRM2CHRM4 | |
| SCHEMBL9492927 | 0.70 | ACE (0.55) | ACEACE2CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512001-B1 | To treat diseases associated with amyloidosis, such as Alzheimer's disease | HOFFMANN-LA ROCHE INC. | 2003-01-28 | — | — | US | disclosed |