Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 0.59 |
| ▸ | PPARA | Q07869 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037295 | 0.91 | PPARG (0.47) | PPARGPPARALMNAHTTGAA | |
| Lithium Ion SCHEMBL7035606 | 0.85 | PPARG (0.70) | PPARGPPARALMNAHTTGAA | |
| Lithium Ion SCHEMBL7036273 | 0.81 | PPARG (0.68) | PPARGPPARALMNAHTTGAA | |
| Lithium Ion SCHEMBL7038128 | 0.80 | PPARG (0.69) | PPARGPPARALMNAHTTGAA | |
| Lithium Ion SCHEMBL7040200 | 0.80 | PPARG (0.70) | PPARGPPARAGAAMEN1KMT2A | |
| SCHEMBL7251721 | 0.79 | PPARG (0.50) | PPARGPPARALMNA | |
| SCHEMBL7037307 | 0.78 | PPARG (0.49) | PPARGPPARALMNAHTTGAA | |
| SCHEMBL7037611 | 0.76 | PPARG (0.66) | PPARGPPARALMNAHTTGAA | |
| SCHEMBL7035613 | 0.76 | PPARG (0.64) | PPARGPPARALMNAHTTGAA | |
| SCHEMBL7038961 | 0.75 | PPARG (0.55) | PPARGPPARALMNAHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630545-B2 | Polymerization catalyst of a metal complex with anionic, polycyclic, fused ring ligand system containing at least 4 fused rings, a cocatalyst and a butadiene or pentadiene | THE DOW CHEMICAL COMPANY | 2003-10-07 | — | — | US | disclosed |
| WO-2003004458-A1 | NEW COMPOUNDS | BIOVITRUM AB (SE) | 2003-01-16 | — | — | WO | disclosed |
| US-20020037981-A1 | Polymerization catalyst of a metal complex with anionic, polycyclic, fused ring ligand system containing at least 4 fused rings, a cocatalyst and a butadiene or pentadiene | DOW CHEMICAL COMPANY | 2002-03-28 | — | — | US | disclosed |