Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 3/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21055788 | 0.78 | HRH4 (0.57) | POLBNR4A2HRH4MEN1KMT2A | |
| SCHEMBL11815143 | 0.76 | ESR1 (0.47) | ESR1ACP1MAP4K4TLR7LATS1 | |
| SCHEMBL21055802 | 0.75 | PDE5A (0.76) | APPPDE5AHRH4MEN1KMT2A | |
| SCHEMBL7254571 | 0.73 | CNR1 (0.52) | CNR1HTT | |
| SCHEMBL3110406 | 0.73 | HTT (0.70) | ACP1APPPDE5APOLBHTT | |
| SCHEMBL7254554 | 0.72 | CNR1 (0.56) | APPPDE5ACNR1CNR2HTT | |
| SCHEMBL25287893 | 0.71 | CSNK2A1 (0.45) | TLR7HTT | |
| SCHEMBL3711032 | 0.71 | ESR1 (0.45) | ESR1ACP1MAP4K4TLR7LATS1 | |
| SCHEMBL1461282 | 0.71 | GSK3B (0.54) | MAP4K4CNR1CNR2 | |
| SCHEMBL4269216 | 0.70 | CYP2D6 (0.63) | TLR7APPPOLBHTTNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003055866-A1 | QUINAZOLINE AND QUINOLINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-10 | — | — | WO | disclosed |