SCHEMBL7255356

SCHEMBL7255356

N#Cc1ccc(Cn2cncc2CN(C(=O)c2ccccc2)c2ccc(-c3ccc(C(=O)O)o3)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FNTA P49354 3/20 0.49
FNTB P49356 3/20 0.49
MAPKAPK2 P49137 8/20 0.49
PGGT1B P53609 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7255227 0.93 CYP11B1 (0.48) FNTAFNTBMAPKAPK2
SCHEMBL7259737 0.92 FNTA (0.51) FNTAFNTBMAPKAPK2PGGT1B
SCHEMBL7255275 0.91 MAPKAPK2 (0.45) FNTAFNTBMAPKAPK2PGGT1B
SCHEMBL7258754 0.90 FNTA (0.48) FNTAFNTBMAPKAPK2
SCHEMBL7255069 0.86 CYP11B1 (0.49) FNTAFNTBMAPKAPK2PGGT1B
SCHEMBL6708505 0.85 MAPKAPK2 (0.52) MAPKAPK2
SCHEMBL7255218 0.84 CYP11B1 (0.48) FNTAFNTBMAPKAPK2PGGT1B
SCHEMBL7255257 0.84 FNTA (0.46) FNTAFNTBMAPKAPK2PGGT1B
SCHEMBL7256035 0.84 FNTA (0.51) FNTAFNTBPGGT1B
SCHEMBL7259654 0.83 CYP11B1 (0.41) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003099812-A1 PHENYL-FURAN OR PHENYL-THIOPHENE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINE PIERRE FABRE MEDICAMENT (FR) 2003-12-04 WO claimed
WO-2003099812-A1 PHENYL-FURAN OR PHENYL-THIOPHENE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINE PIERRE FABRE MEDICAMENT (FR) 2003-12-04 WO disclosed