Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.51 |
| ▸ | AKT2 | P31751 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15656164 | 0.83 | GSK3B (0.41) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL1226044 | 0.81 | CDK5 (0.59) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL1226239 | 0.80 | GSK3B (0.51) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL1460288 | 0.80 | GSK3B (0.51) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL1227014 | 0.76 | GSK3B (0.73) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL1459087 | 0.75 | GSK3B (0.58) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL1227491 | 0.75 | GSK3B (0.52) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL1459104 | 0.75 | GSK3B (0.52) | GSK3BGSK3ARPS6KA5CDK1CSF1R | |
| SCHEMBL2929958 | 0.75 | AKT2 (0.44) | GSK3BAKT2CHEK1KMT2AGRM5 | |
| SCHEMBL1458522 | 0.75 | GSK3B (0.46) | GSK3BGSK3ARPS6KA5CDK1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |