Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.77 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.77 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.77 |
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104668 | 0.88 | AXL (0.53) | AXLMKNK1MKNK2FADS1ADORA2A | |
| SCHEMBL29365402 | 0.88 | AXL (0.53) | AXLMKNK1MKNK2FADS1ADORA2A | |
| SCHEMBL659673 | 0.88 | AXL (1.00) | AXLMKNK1MKNK2FADS1ADORA2A | |
| SCHEMBL29991404 | 0.88 | AXL (1.00) | AXLMKNK1MKNK2FADS1ADORA2A | |
| SCHEMBL660369 | 0.65 | AXL (0.48) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL4037241 | 0.65 | AXL (0.44) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL29631094 | 0.65 | AXL (0.44) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL21393430 | 0.65 | AXL (0.44) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL29377266 | 0.65 | AXL (0.48) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL29368189 | 0.65 | AXL (0.44) | AXLMKNK1MKNK2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003000194-A2 | THIENOPYRIDINE AND THIENOPYRIMIDINE ANTICANCER AGENTS | PFIZER INC. (US) | 2003-01-03 | — | — | WO | disclosed |