Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | USP8 | P40818 | 1/20 | 0.45 |
| ▸ | USP7 | Q93009 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412287 | 0.87 | ESR2 (0.60) | ESR2KDM4EPTPN5USP8USP7 | |
| SCHEMBL222 | 0.87 | ESR2 (0.60) | ESR2KDM4EPTPN5USP8USP7 | |
| SCHEMBL1343584 | 0.86 | CYP3A4 (0.49) | ESR2KDM4EGAAPPIACA1 | |
| SCHEMBL10697723 | 0.84 | CYP3A4 (0.47) | ESR2GAAUSP8USP7PPIA | |
| SCHEMBL14114868 | 0.81 | TTR (0.51) | ESR2ALDH1A1HPGD | |
| SCHEMBL7559438 | 0.81 | AKR1C3 (0.48) | ESR2GAAATMPPIACRHBP | |
| Bicarbonate SCHEMBL11598084 | 0.80 | ESR2 (0.41) | ESR2KDM4EGAAPTPN5USP8 | |
| SCHEMBL1285853 | 0.79 | ESR2 (0.59) | ESR2KDM4EGAAPTPN5USP8 | |
| Bicarbonate SCHEMBL15521922 | 0.79 | KDM4E (0.46) | ESR2KDM4EGAATSHRFFAR1 | |
| SCHEMBL565467 | 0.79 | ESR2 (0.59) | ESR2KDM4EGAAPTPN5USP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642322-B2 | Reacting a substrate compound selected from polycarbonate, polyester, polyurethanes, polylactones with a chain transfer agent to form telechelic oligomers in presence of alkali metal catalyst; living free radical polymerization | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2003-11-04 | — | — | US | disclosed |
| US-20020115793-A1 | Methods of making telechelic oligomers, methods of making block copolymers, and novel block copolymers | GAGNE MICHEL R (US) | 2002-08-22 | — | — | US | disclosed |