Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 15/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446404 | 0.97 | TYMS (0.77) | TYMS | |
| SCHEMBL6446395 | 0.97 | TYMS (0.77) | TYMS | |
| SCHEMBL9236881 | 0.94 | TYMS (0.85) | TYMS | |
| SCHEMBL7257380 | 0.92 | TYMS (0.66) | TYMS | |
| SCHEMBL7258003 | 0.89 | TYMS (0.71) | TYMS | |
| SCHEMBL7257755 | 0.88 | TYMS (0.94) | TYMS | |
| SCHEMBL7900670 | 0.87 | TYMS (0.79) | TYMS | |
| SCHEMBL6654917 | 0.86 | TYMS (0.60) | TYMS | |
| SCHEMBL6654911 | 0.86 | TYMS (0.60) | TYMS | |
| SCHEMBL7257746 | 0.84 | TYMS (0.64) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728018-B1 | New enzymes and prodrugs for ADEPT | WELLCOME FOUND (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-6319702-B1 | NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER | GLAXO WELLCOME, INC. | 2001-11-20 | — | — | US | disclosed |
| EP-0728018-A1 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013095-A2 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |