Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 13/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 13/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100335 | 1.00 | PDE3B (0.41) | PDE3BPDE3AGRIN1GRIN2BCHEK1 | |
| SCHEMBL7019405 | 0.77 | FEN1 (0.56) | — | |
| SCHEMBL7019409 | 0.77 | FEN1 (0.56) | — | |
| SCHEMBL7014592 | 0.71 | FEN1 (0.35) | — | |
| SCHEMBL7014590 | 0.71 | FEN1 (0.35) | — | |
| SCHEMBL7020404 | 0.71 | KDM4E (0.45) | — | |
| SCHEMBL7020408 | 0.71 | KDM4E (0.45) | — | |
| SCHEMBL7022651 | 0.70 | — | — | |
| SCHEMBL7022655 | 0.70 | — | — | |
| SCHEMBL11236623 | 0.69 | GRIN1 (0.55) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |