Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ABL1 | P00519 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | IDE | P14735 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | HLCS | P50747 | 6/20 | 0.59 |
| ▸ | CA12 | O43570 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28283183 | 0.94 | TDP1 (0.81) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL28119479 | 0.94 | TDP1 (0.81) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL21114407 | 0.94 | TDP1 (0.81) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL21176811 | 0.94 | TDP1 (0.81) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL22265330 | 0.92 | TDP1 (0.79) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL28516361 | 0.89 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL2589782 | 0.88 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL34456 | 0.88 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL20473406 | 0.88 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL28157478 | 0.88 | TDP1 (0.76) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346730-A1 | Pretargeting methods and novel pretargeting conjugates | NEORX CORPORATION (US) | 2003-09-24 | — | — | EP | disclosed |
| US-6217869-B1 | ADMINISTERING ANTIBODY, ANTIGEN, LIGAND COMPLEX | NEORX CORPORATION | 2001-04-17 | — | — | US | disclosed |
| US-6015897-A | FOR CONJUGATION TO LIGAND/ANTILIGAND PAIR AND USE IN DELIVERY OF THERAPEUTIC OR DIAGNOSTIC AGENT TO TARGETED SITE | NEORX CORPORATION (US) | 2000-01-18 | — | — | US | disclosed |
| US-5976535-A | ADMINISTERING A FIRST CONJUGATE COMPRISING A TARGETING MOIETY AND STREPTAVIDIN; AND SUBSEQUENTLY ADMINISTERING A SECOND CONJUGATE COMPRISING A CYTOKINE AND BIOTIN, REDUCING THE ENDOGENOUS BIOTIN LEVEL | NEORX CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0733066-A4 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORP (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0733066-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015979-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |