Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17459806 | 0.88 | FLT3 (0.47) | FLT3MAPTKDM4EGPR3NOS1 | |
| SCHEMBL19006332 | 0.85 | FLT3 (0.43) | FLT3GRM4MAPTKDM4EGPR3 | |
| SCHEMBL17469773 | 0.83 | FLT3 (0.52) | FLT3GRM5SMN1; SMN2 | |
| SCHEMBL17469783 | 0.83 | FLT3 (0.52) | FLT3GRM5F12PLAUASIC3 | |
| SCHEMBL17469805 | 0.81 | FLT3 (0.71) | FLT3MAPTGRM5KDM4EGPR3 | |
| SCHEMBL21152882 | 0.80 | FLT3 (0.39) | FLT3APPCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7258744 | 0.77 | KDM4E (0.42) | MAPTKDM4EGPR3NOS1NPC1 | |
| SCHEMBL23599649 | 0.77 | FLT3 (0.52) | FLT3GRM5NOS1F12PLAU | |
| SCHEMBL7253831 | 0.75 | KDM4E (0.46) | FLT3KDM4EGPR3NOS1MEN1 | |
| SCHEMBL28392347 | 0.72 | APP (0.52) | MAPTAPPADORA2AGRM5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024931-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-03-27 | — | — | WO | claimed |
| WO-2003024931-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-03-27 | — | — | WO | disclosed |