SCHEMBL7259448

SCHEMBL7259448

CSC1=C(N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cncc3Cl)cc2)C(=O)O)C2(CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC2)C1=O

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 20/20 0.61
ITGA4 P13612 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3882857 1.00 ITGB1 (0.61) ITGB1ITGA4
SCHEMBL2978069 1.00 ITGB1 (0.61) ITGB1ITGA4
SCHEMBL6131673 0.93 ITGB1 (0.61) ITGB1ITGA4
SCHEMBL2982319 0.93 ITGB1 (0.61) ITGB1ITGA4
SCHEMBL2987842 0.92 ITGB1 (0.51) ITGB1ITGA4
SCHEMBL2986247 0.90 ITGB1 (0.64) ITGB1ITGA4
SCHEMBL7259871 0.90 ITGB1 (0.64) ITGB1ITGA4
SCHEMBL2982318 0.90 ITGB1 (0.64) ITGB1ITGA4
SCHEMBL2984930 0.90 ITGB1 (0.61) ITGB1ITGA4
SCHEMBL3857893 0.90 ITGB1 (0.61) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1370531-A1 PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS Celltech R & D Limited (GB) 2003-12-17 EP disclosed
WO-2002068393-A1 PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS CELLTECH R & D LIMITED (GB) 2002-09-06 WO disclosed