Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PRSS8 | Q16651 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5703665 | 1.00 | ATM (0.35) | ATMTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7260203 | 0.83 | ATM (0.39) | ATMCTSLCTSBCTSSPRSS8 | |
| SCHEMBL5704088 | 0.77 | PPARG (0.33) | TP53SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL5460212 | 0.70 | ATM (0.40) | ATMCTSLCTSBCTSK | |
| SCHEMBL5946038 | 0.70 | ATM (0.40) | ATMCTSLCTSBCTSK | |
| SCHEMBL5460216 | 0.70 | ATM (0.40) | ATMCTSLCTSBCTSK | |
| SCHEMBL5460207 | 0.70 | ATM (0.40) | ATMCTSLCTSBCTSK | |
| SCHEMBL12221562 | 0.69 | ATM (0.51) | ATMTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7260207 | 0.69 | PTGER4 (0.43) | CTSLCTSBCTSSCTSK | |
| SCHEMBL6628452 | 0.68 | PTPN1 (0.40) | ATMSMN1; SMN2LMNACTSKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004000838-A1 | PEPTIDIC COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2003-12-31 | — | — | WO | disclosed |