Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7260629 | 1.00 | PDE4A (0.75) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8659267 | 0.92 | PDE4A (0.74) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7260669 | 0.91 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7260664 | 0.91 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7396439 | 0.90 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7396442 | 0.90 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7264868 | 0.86 | PDE4A (0.76) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7264867 | 0.86 | PDE4A (0.76) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7907449 | 0.85 | PDE4A (0.85) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3759110 | 0.83 | PDE4A (0.86) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874824-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2003-06-25 | — | — | EP | claimed |
| US-5849770-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1998-12-15 | — | — | US | claimed |
| EP-0874824-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2003-06-25 | — | — | EP | disclosed |
| US-5849770-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1998-12-15 | — | — | US | disclosed |