SCHEMBL726080

SCHEMBL726080

COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2OC(=O)NCc2ccc(F)cc2F)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 2/20 0.77
KCNK3 O14649 2/20 0.77
KCNK5 O95279 1/20 0.77
KCNK17 Q96T54 1/20 0.77
KCNK9 Q9NPC2 1/20 0.77
NPC1 O15118 2/20 0.48
MEN1 O00255 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
KCNH2 Q12809 1/20 0.47
ALDH1A1 P00352 3/20 0.47
POLB P06746 1/20 0.47
FAAH O00519 2/20 0.45
ERCC1 P07992 1/20 0.43
ERCC4 Q92889 1/20 0.43
DGAT2 Q96PD7 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL498641 0.87 KCNA5 (1.00) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL4234451 0.83 KCNA5 (0.79) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL4234905 0.83 KCNA5 (0.78) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL12434045 0.82 KCNA5 (0.78) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL4231221 0.81 KCNA5 (0.85) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL4231667 0.80 KCNA5 (0.79) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL5697876 0.79 KCNA5 (0.52) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL12434336 0.79 KCNA5 (0.84) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL5697841 0.79 KCNA5 (0.53) KCNA5KCNK3KCNK5KCNK17KCNK9
SCHEMBL5697868 0.79 KCNA5 (0.76) KCNA5KCNK3KCNK5KCNK17KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4658919-B2 2011-03-23 JP claimed
EP-1720549-A1 KV1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY Sanofi-Aventis Deutschland GmbH (DE) 2006-11-15 EP claimed
JP-2006520342-A 2006-09-07 JP claimed
EP-1670551-A1 COMBINATION OF PHENYLCARBOXAMIDES WITH BETA-ADRENERGIC RECEPTOR BLOCKERS AND USE THEREOF FOR THE TREATMENT OF ATRIAL ARRHYTHMIAS Sanofi-Aventis Deutschland GmbH (DE) 2006-06-21 EP claimed
EP-1605976-A1 PHENYLCARBOXYL ACID AMIDES AND IK r CHANNEL INHIBITORS COMBINATION AND THE USE THEREOF FOR TREATING ATRIAL ARRHYTHMIA Sanofi-Aventis Deutschland GmbH (DE) 2005-12-21 EP claimed
WO-2005084675-A1 KV1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-09-15 WO claimed
WO-2005025674-A1 COMBINATION OF PHENYLCARBOXAMIDES WITH BETA-ADRENERGIC RECEPTOR BLOCKERS AND USE THEREOF FOR THE TREATMENT OF ATRIAL ARRHYTHMIAS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-03-24 WO claimed
WO-2004082716-A1 PHENYLCARBOXYL ACID AMIDES AND IKr CHANNEL INHIBITORS COMBINATION AND THE USE THEREOF FOR TREATING ATRIAL ARRHYTHMIA SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2004-09-30 WO claimed
EP-1720549-A1 KV1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY Sanofi-Aventis Deutschland GmbH (DE) 2006-11-15 EP disclosed
EP-1222163-B1 2'-SUBSTITUTED 1,1'-BIPHENYL-2-CARBONAMIDES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS SANOFI AVENTIS DEUTSCHLAND (DE) 2006-07-12 EP disclosed
EP-1670551-A1 COMBINATION OF PHENYLCARBOXAMIDES WITH BETA-ADRENERGIC RECEPTOR BLOCKERS AND USE THEREOF FOR THE TREATMENT OF ATRIAL ARRHYTHMIAS Sanofi-Aventis Deutschland GmbH (DE) 2006-06-21 EP disclosed
EP-1605976-A1 PHENYLCARBOXYL ACID AMIDES AND IK r CHANNEL INHIBITORS COMBINATION AND THE USE THEREOF FOR TREATING ATRIAL ARRHYTHMIA Sanofi-Aventis Deutschland GmbH (DE) 2005-12-21 EP disclosed
WO-2005084675-A1 KV1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-09-15 WO disclosed
WO-2005025674-A1 COMBINATION OF PHENYLCARBOXAMIDES WITH BETA-ADRENERGIC RECEPTOR BLOCKERS AND USE THEREOF FOR THE TREATMENT OF ATRIAL ARRHYTHMIAS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-03-24 WO disclosed
WO-2004082716-A1 PHENYLCARBOXYL ACID AMIDES AND IKr CHANNEL INHIBITORS COMBINATION AND THE USE THEREOF FOR TREATING ATRIAL ARRHYTHMIA SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2004-09-30 WO disclosed
EP-1222163-A1 2'-SUBSTITUTED 1,1'-BIPHENYL-2-CARBONAMIDES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS Aventis Pharma Deutschland GmbH (DE) 2002-07-17 EP disclosed
WO-2001025189-A1 2'-SUBSTITUTED 1,1'-BIPHENYL-2-CARBONAMIDES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-04-12 WO disclosed