Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Afn-1252. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Afn-1252 SCHEMBL726232 | 1.00 | — | — | |
| Afn-1252 SCHEMBL726628 | 0.98 | — | — | |
| Afn-1252 SCHEMBL726627 | 0.98 | — | — | |
| Afn-1252 SCHEMBL726870 | 0.97 | — | — | |
| Afn-1252 SCHEMBL726869 | 0.97 | — | — | |
| Afn-1252 SCHEMBL29603927 | 0.97 | — | — | |
| Afn-1252 SCHEMBL726875 | 0.97 | — | — | |
| Afn-1252 SCHEMBL724936 | 0.97 | — | — | |
| Afn-1252 SCHEMBL29378725 | 0.97 | — | — | |
| Afn-1252 SCHEMBL724937 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140309191-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2014-10-16 | — | — | US | claimed |
| US-20130150400-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2013-06-13 | — | — | US | claimed |
| EP-2125802-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | Affinium Pharmaceuticals, Inc. (CA) | 2009-12-02 | — | — | EP | claimed |
| US-20090042927-A1 | Salts, Prodrugs and Polymorphs of Fab I Inhibitors | DEBIOPHARM INTERNATIONAL SA (CH) | 2009-02-12 | — | — | US | claimed |
| WO-2008098374-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2008-08-21 | — | — | WO | claimed |
| US-9862737-B2 | Salts, prodrugs and polymorphs of fab I inhibitors | DEBIOPHARM INTERNATIONAL SA (CH) | 2018-01-09 | — | — | US | disclosed |
| US-20140309191-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2014-10-16 | — | — | US | disclosed |
| US-20130281442-A1 | Compounds for Treatment of Bovine Mastitis | DEBIOPHARM INTERNATIONAL SA (CH) | 2013-10-24 | — | — | US | disclosed |
| US-20130150400-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2013-06-13 | — | — | US | disclosed |
| EP-2579863-A2 | COMPOUNDS FOR TREATMENT OF BOVINE MASTITIS | Affinium Pharmaceuticals, Inc. (CA) | 2013-04-17 | — | — | EP | disclosed |
| US-8263613-B2 | Salts, prodrugs and polymorphs of fab I inhibitors | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2012-09-11 | — | — | US | disclosed |
| WO-2011156811-A2 | COMPOUNDS FOR TREATMENT OF BOVINE MASTITIS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2011-12-15 | — | — | WO | disclosed |
| EP-2125802-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | Affinium Pharmaceuticals, Inc. (CA) | 2009-12-02 | — | — | EP | disclosed |
| EP-2118097-A1 | 1-OXA-3-AZASPIRO[4,5]DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | disclosed |
| US-20090042927-A1 | Salts, Prodrugs and Polymorphs of Fab I Inhibitors | DEBIOPHARM INTERNATIONAL SA (CH) | 2009-02-12 | — | — | US | disclosed |
| WO-2008098374-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008092891-A1 | 1-OXA-3-AZASPIRO(4.5)DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092888-A1 | 1-OXA-3-AZASPIRO[4,5]DECAN--2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-08-07 | — | — | WO | disclosed |