SCHEMBL7262986

SCHEMBL7262986

CCOC(=O)[C@@H](N)Cc1cccc2ccccc12

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.50
CTNNB1 P35222 1/20 0.49
ALDH1A1 P00352 2/20 0.48
HPGD P15428 2/20 0.48
SLC1A3 P43003 1/20 0.47
SLC1A2 P43004 1/20 0.47
SLC1A1 P43005 1/20 0.47
CDC25B P30305 1/20 0.47
TACR1 P25103 4/20 0.46
SCN9A Q15858 1/20 0.46
KDM4E B2RXH2 1/20 0.45
APOBEC3A P31941 1/20 0.45
APOBEC3G Q9HC16 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
LMNA P02545 1/20 0.45
MAPT P10636 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3936305 1.00 KMT2A (0.50) KMT2ACTNNB1ALDH1A1HPGDSLC1A3
SCHEMBL8465002 1.00 KMT2A (0.50) KMT2ACTNNB1ALDH1A1HPGDSLC1A3
Hydrochloric Acid SCHEMBL7257593 0.99 KMT2A (0.49) KMT2ACTNNB1ALDH1A1HPGDSLC1A3
SCHEMBL6018293 0.87 ATM (0.50) CTNNB1ALDH1A1SLC1A3SLC1A2SLC1A1
SCHEMBL1902233 0.87 ATM (0.50) CTNNB1ALDH1A1SLC1A3SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL9632609 0.85 ATM (0.49) CTNNB1ALDH1A1SLC1A3SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL7066174 0.85 ATM (0.49) CTNNB1ALDH1A1SLC1A3SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL9630734 0.85 ATM (0.49) CTNNB1ALDH1A1SLC1A3SLC1A2SLC1A1
SCHEMBL6719502 0.85 CTNNB1 (0.59) KMT2ACTNNB1ALDH1A1HPGDCDC25B
SCHEMBL6176215 0.84 KMT2A (0.51) KMT2ACTNNB1ALDH1A1HPGDCDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0728018-B1 New enzymes and prodrugs for ADEPT WELLCOME FOUND (GB) 2003-08-06 EP disclosed
US-6319702-B1 NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER GLAXO WELLCOME, INC. 2001-11-20 US disclosed
US-6140100-A CONJUGATE POLYPEPTIDE WHICH IS TISSUE PREFERENTIAL; ANTICARCINOGENIC AGENTS GLAXO WELLCOME INC. (US) 2000-10-31 US disclosed