Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.88 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.84 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.84 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265246 | 1.00 | PDE4A (0.88) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6890082 | 0.98 | PDE4A (0.84) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6890078 | 0.98 | PDE4A (0.84) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6887756 | 0.95 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL6889288 | 0.94 | PDE4A (0.80) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL6889284 | 0.94 | PDE4A (0.80) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387472 | 0.93 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387378 | 0.93 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387380 | 0.93 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6755361 | 0.93 | PDE4A (0.95) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874824-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2003-06-25 | — | — | EP | disclosed |
| EP-0874824-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997023461-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-07-03 | — | — | WO | disclosed |