SCHEMBL7265382

SCHEMBL7265382

O=C(Nc1ccc(C[C@H](NC2=C(Br)OC23CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC3)C(=O)O)nc1)c1c(Cl)cncc1Cl

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 20/20 0.49
ITGA4 P13612 20/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2982291 1.00 ITGB1 (0.49) ITGB1ITGA4
Hydrochloric Acid SCHEMBL2986765 0.99 ITGB1 (0.48) ITGB1ITGA4
SCHEMBL2976081 0.92 ITGB1 (0.49) ITGB1ITGA4
Hydrochloric Acid SCHEMBL5573468 0.92 ITGB1 (0.49) ITGB1ITGA4
SCHEMBL3835185 0.90 ITGB1 (0.42) ITGB1ITGA4
Hydrochloric Acid SCHEMBL3831968 0.89 ITGB1 (0.41) ITGB1ITGA4
SCHEMBL5669327 0.89 ITGB1 (0.47) ITGB1ITGA4
SCHEMBL5670531 0.87 ITGB1 (0.46) ITGB1ITGA4
SCHEMBL2990133 0.86 ITGB1 (0.49) ITGB1ITGA4
SCHEMBL2982582 0.85 ITGB1 (0.49) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1370531-A1 PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS Celltech R & D Limited (GB) 2003-12-17 EP disclosed
WO-2002068393-A1 PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS CELLTECH R & D LIMITED (GB) 2002-09-06 WO disclosed