SCHEMBL7265684

SCHEMBL7265684

CC1=C(C(=O)O)C(c2ccccc2C(F)(F)F)N(C(N)=O)C(=O)N1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 5/20 0.51
CACNA1F O60840 2/20 0.51
CACNA1D Q01668 2/20 0.51
CACNA1S Q13698 2/20 0.51
CYP1A2 P05177 3/20 0.43
CYP3A4 P08684 3/20 0.43
ADORA3 P0DMS8 3/20 0.43
MAPT P10636 3/20 0.43
CYP2C9 P11712 3/20 0.43
CYP2C19 P33261 3/20 0.43
TSHR P16473 2/20 0.43
NFKB1 P19838 2/20 0.43
MEN1 O00255 1/20 0.43
CYP2D6 P10635 1/20 0.43
KMT2A Q03164 1/20 0.43
TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9476150 0.90 CACNA1C (0.53) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7384493 0.81 CACNA1C (0.65) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL9474870 0.81 CACNA1C (0.65) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7266717 0.80 CACNA1C (0.44) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL9672747 0.78 CACNA1C (0.58) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL9477546 0.78 CACNA1C (0.44) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10640720 0.76 CACNA1C (0.44) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL10377399 0.74 CACNA1C (0.44) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL10359259 0.74 CACNA1C (0.43) CACNA1CCACNA1FCACNA1DCACNA1STP53
SCHEMBL7271694 0.73 KMT2A (0.48) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0237347-B1 1,2,3,4-Tetrahydro-6-substituted-4-aryl (or heterocyclo)-3-[(substituted amino)carbonyl]-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters E.R. Squibb & Sons, Inc. (US) 1991-06-12 EP disclosed
US-4855301-A 1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters E. R. SQUIBB & SONS, INC. (US) 1989-08-08 US disclosed
EP-0237347-A2 1,2,3,4-Tetrahydro-6-substituted-4-aryl (or heterocyclo)-3-[(substituted amino)carbonyl]-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters E.R. Squibb & Sons, Inc. (US) 1987-09-16 EP disclosed