Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | KDM1A | O60341 | 1/20 | 0.76 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | GFER | P55789 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.65 |
| ▸ | PREP | P48147 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265734 | 1.00 | KDM4E (0.78) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL13388185 | 0.94 | KDM4E (0.77) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL4387714 | 0.93 | KDM4E (0.76) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL13588884 | 0.93 | KDM4E (0.76) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL4397563 | 0.93 | KDM4E (0.76) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL13588907 | 0.93 | KDM4E (0.76) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL4382112 | 0.92 | KDM4E (0.74) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL12755446 | 0.92 | KDM4E (0.78) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL4388740 | 0.92 | KDM4E (0.74) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL13230392 | 0.92 | KDM1A (0.75) | KDM4ELMNAHSD17B10NPSR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4636567-A | CNS DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1987-01-13 | — | — | US | disclosed |
| US-4610821-A | CENTRAL NERVOUS SYSTEM, THYROTROPIN RELEASING HORMONE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-09-09 | — | — | US | disclosed |
| US-4564609-A | NERVOUS SYSTEM DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-01-14 | — | — | US | disclosed |
| EP-0123444-A1 | 4-Substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |