Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 4/20 | 0.72 |
| ▸ | RET | P07949 | 11/20 | 0.53 |
| ▸ | KDR | P35968 | 11/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | BTK | Q06187 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | FYN | P06241 | 2/20 | 0.53 |
| ▸ | YES1 | P07947 | 2/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | FRK | P42685 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728150 | 0.93 | RIPK2 (0.77) | RIPK2RETKDREGFRBTK | |
| SCHEMBL726638 | 0.90 | RIPK2 (0.72) | RIPK2RETKDREGFRBTK | |
| SCHEMBL726858 | 0.90 | RIPK2 (0.72) | RIPK2RETKDREGFRBTK | |
| SCHEMBL726399 | 0.89 | RIPK2 (0.71) | RIPK2RETKDREGFRBTK | |
| SCHEMBL726666 | 0.88 | RIPK2 (0.70) | RIPK2RETKDREGFRBTK | |
| SCHEMBL726721 | 0.88 | RIPK2 (0.77) | RIPK2RETKDREGFRBTK | |
| SCHEMBL728243 | 0.87 | RIPK2 (0.71) | RIPK2RETKDREGFRBTK | |
| SCHEMBL15114632 | 0.87 | RIPK2 (0.73) | RIPK2RETKDREGFRBTK | |
| SCHEMBL727113 | 0.86 | RIPK2 (0.67) | RIPK2RETKDREGFRBTK | |
| SCHEMBL728531 | 0.86 | RIPK2 (0.77) | RIPK2RETKDREGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003544-A1 | PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-12 | — | — | WO | disclosed |