Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378456 | 0.84 | RXFP1 (0.50) | RXFP1PTGS1PTGS2KDM4EPOLB | |
| SCHEMBL7268780 | 0.80 | KDM4E (0.59) | RXFP1KDM4EPOLBRAB9AALDH1A1 | |
| SCHEMBL1758978 | 0.80 | RXFP1 (0.56) | RXFP1PTGS1PTGS2KDM4EPOLB | |
| SCHEMBL3305733 | 0.71 | PTGS1 (0.56) | RXFP1PTGS1PTGS2KDM4EPOLB | |
| SCHEMBL23571486 | 0.71 | PTGS1 (0.47) | RXFP1PTGS1PTGS2KDM4EPOLB | |
| SCHEMBL2505187 | 0.71 | PTGS1 (0.51) | RXFP1PTGS1PTGS2KDM4ETDP1 | |
| SCHEMBL26922447 | 0.71 | PTGS1 (0.44) | RXFP1PTGS1PTGS2KDM4ETDP1 | |
| SCHEMBL19660422 | 0.70 | PTGS1 (0.54) | RXFP1PTGS1PTGS2KDM4ETDP1 | |
| SCHEMBL30556624 | 0.70 | PTGS1 (0.54) | RXFP1PTGS1PTGS2KDM4ETDP1 | |
| SCHEMBL8373781 | 0.70 | PTGS1 (0.54) | RXFP1PTGS1PTGS2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0370381-A2 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |