Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | WHR1 | P49842 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262033 | 0.91 | KMT2A (0.54) | PDE10AKMT2AMEN1HTTTP53 | |
| SCHEMBL7267747 | 0.90 | PDE10A (0.65) | PDE10AKMT2AMEN1HTTTP53 | |
| SCHEMBL7262660 | 0.84 | HTT (0.68) | KMT2AMEN1HTTTP53MAPT | |
| SCHEMBL7262687 | 0.82 | MEN1 (0.65) | KMT2AMEN1HTTTP53MAPT | |
| SCHEMBL7267768 | 0.82 | MEN1 (0.60) | KMT2AMEN1HTTTP53MAPT | |
| SCHEMBL7262644 | 0.80 | MEN1 (0.71) | KMT2AMEN1HTTTP53MAPT | |
| SCHEMBL7261431 | 0.80 | HTT (0.56) | KMT2AMEN1HTTTP53MAPT | |
| Hydrochloric Acid SCHEMBL7266371 | 0.79 | POLB (0.47) | KMT2AMEN1HTTTP53MAPT | |
| Acetic Acid SCHEMBL7268584 | 0.77 | WHR1 (0.49) | KMT2AMEN1HTTTP53MAPT | |
| SCHEMBL7268476 | 0.76 | MEN1 (0.60) | KMT2AMEN1HTTTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |