Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268793 | 1.00 | CRBN (0.53) | CRBNDDB1MAPK1NPSR1PPARG | |
| SCHEMBL4394121 | 0.83 | CRBN (0.46) | CRBNDDB1TDP1 | |
| SCHEMBL4394120 | 0.83 | CRBN (0.46) | CRBNDDB1TDP1 | |
| SCHEMBL4399379 | 0.79 | CRBN (0.56) | CRBNDDB1IKZF3 | |
| SCHEMBL4388040 | 0.79 | CRBN (0.56) | CRBNDDB1IKZF3 | |
| SCHEMBL4388041 | 0.79 | CRBN (0.56) | CRBNDDB1IKZF3 | |
| SCHEMBL6690877 | 0.79 | CRBN (0.60) | CRBNDDB1IKZF3 | |
| SCHEMBL4400886 | 0.78 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL4400882 | 0.78 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL4388045 | 0.75 | CRBN (0.54) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656937-B2 | Immunology moderators; interleukin antagonist; anticancer agents | GRUENENTHAL, GMBH (DE) | 2003-12-02 | — | — | US | claimed |
| US-6656937-B2 | Immunology moderators; interleukin antagonist; anticancer agents | GRUENENTHAL, GMBH (DE) | 2003-12-02 | — | — | US | disclosed |