SCHEMBL7269148

SCHEMBL7269148

CC(C)CC(N)[C@@H](O)c1ccccn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.43
CYP1A2 P05177 2/20 0.43
KCNA5 P22460 5/20 0.41
TSHR P16473 2/20 0.41
SLC6A2 P23975 3/20 0.41
SLC6A4 P31645 3/20 0.41
KCNH2 Q12809 2/20 0.41
SLC6A3 Q01959 2/20 0.41
CYP2D6 P10635 2/20 0.41
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 2/20 0.38
KCNE1 P15382 1/20 0.37
TP53 P04637 1/20 0.37
KCNJ5 P48544 1/20 0.37
KCNJ3 P48549 1/20 0.37
SCN5A Q14524 1/20 0.37
KCND3 Q9UK17 1/20 0.37
CHRM2 P08172 1/20 0.36
SCN1A P35498 1/20 0.36
SCN2A Q99250 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7269150 1.00 CYP3A4 (0.43) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL7268109 1.00 CYP3A4 (0.43) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL7269144 1.00 CYP3A4 (0.43) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL7268101 1.00 CYP3A4 (0.43) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL7268105 1.00 CYP3A4 (0.43) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL4969094 0.80 KDM4E (0.50) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL5227874 0.80 KDM4E (0.50) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL16124412 0.79 TSHR (0.46) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL6853387 0.79 TSHR (0.46) CYP3A4CYP1A2KCNA5TSHRSLC6A2
SCHEMBL8297661 0.79 TSHR (0.46) CYP3A4CYP1A2KCNA5TSHRSLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0376040-A2 N-phosphinyl di-and tripeptides as renin inhibitors AMERICAN CYANAMID COMPANY (US) 1990-07-04 EP disclosed