Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12096427 | 1.00 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL4083324 | 1.00 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL3305502 | 1.00 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL765258 | 1.00 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL13378898 | 1.00 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL4367463 | 0.94 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL4367460 | 0.94 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL17961679 | 0.94 | BTK (0.46) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL1988095 | 0.89 | BTK (0.47) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL4713065 | 0.88 | BTK (0.45) | BTKKDM1AGAAMAOBNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270557-B1 | ETHYLENEDIAMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-1270557-A1 | ETHYLENEDIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |