SCHEMBL7269771

SCHEMBL7269771

C[C@@H](O)Cn1ccc(N)nc1=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 4/20 0.52
SLC22A6 Q4U2R8 1/20 0.51
KDM4E B2RXH2 1/20 0.41
LMNA P02545 5/20 0.38
ADORA2A P29274 1/20 0.38
ADORA1 P30542 1/20 0.38
EP300 Q09472 5/20 0.37
THRB P10828 1/20 0.37
MTOR P42345 1/20 0.37
MDM2 Q00987 1/20 0.37
NCOA1 Q15788 1/20 0.37
NCOA3 Q9Y6Q9 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
PDE3A Q14432 3/20 0.35
CACNA1F O60840 2/20 0.35
ALB P02768 2/20 0.35
MAPT P10636 2/20 0.35
CACNA1D Q01668 2/20 0.35
CACNA1S Q13698 2/20 0.35
CACNA1C Q13936 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7269776 1.00 FGFR1 (0.52) FGFR1SLC22A6KDM4ELMNAADORA2A
SCHEMBL12652844 0.86 FGFR1 (0.51) FGFR1SLC22A6LMNAADORA2AEP300
SCHEMBL14478248 0.85 FGFR1 (0.50) FGFR1SLC22A6
SCHEMBL18069556 0.84 FGFR1 (0.50) FGFR1SLC22A6LMNAEP300THRB
SCHEMBL140792 0.84 FGFR1 (0.50) FGFR1SLC22A6LMNAEP300THRB
SCHEMBL10049650 0.84 FGFR1 (0.56) FGFR1SLC22A6LMNAEP300THRB
SCHEMBL14948806 0.84 FGFR1 (0.56) FGFR1SLC22A6LMNAEP300THRB
SCHEMBL25926303 0.83 FGFR1 (0.49) FGFR1SLC22A6LMNAEP300THRB
SCHEMBL16039335 0.83 FGFR1 (0.53) FGFR1SLC22A6LMNAEP300THRB
SCHEMBL16038518 0.83 FGFR1 (0.53) FGFR1SLC22A6LMNAEP300THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6653296-B1 2-phosphonomethoxypropyl derivatives of purine and pyrimidine bases INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2003-11-25 US disclosed
US-6479673-B1 Antiretroviral enantiomeric nucleotide analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2002-11-12 US disclosed
US-6057305-A Antiretroviral enantiomeric nucleotide analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2000-05-02 US disclosed
EP-0654037-B1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1999-05-12 EP disclosed
EP-0654037-A1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1995-05-24 EP disclosed
WO-1994003467-A2 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1994-02-17 WO disclosed