SCHEMBL726987 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	RET	P07949	9/20	0.71

▸	RIPK2	O43353	4/20	0.37

▸	SRC	P12931	9/20	0.33

▸	ABL1	P00519	5/20	0.33

▸	KDM4E	B2RXH2	2/20	0.33

▸	ALDH1A1	P00352	2/20	0.33

▸	EGFR	P00533	2/20	0.33

▸	LMNA	P02545	2/20	0.33

▸	LCK	P06239	2/20	0.33

▸	FYN	P06241	2/20	0.33

▸	YES1	P07947	2/20	0.33

▸	LYN	P07948	2/20	0.33

▸	PDGFRA	P16234	2/20	0.33

▸	PRKACA	P17612	2/20	0.33

▸	KDR	P35968	2/20	0.33

▸	FRK	P42685	2/20	0.33

▸	HTT	P42858	2/20	0.33

▸	MAPK9	P45984	2/20	0.33

▸	CSNK1A1	P48729	2/20	0.33

▸	CSNK1D	P48730	2/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL726637	0.89	RET (0.76)	RETRIPK2SRCABL1KDM4E
SCHEMBL726560	0.87	RET (0.69)	RETRIPK2SRCABL1KDM4E
SCHEMBL726543	0.86	RET (0.80)	RETRIPK2SRCABL1KDM4E
SCHEMBL728046	0.85	RET (0.69)	RETRIPK2SRCABL1KDM4E
SCHEMBL728202	0.85	RET (0.69)	RETRIPK2SRCABL1KDM4E
SCHEMBL726539	0.85	RET (0.66)	RETRIPK2SRCEGFRLCK
SCHEMBL726969	0.84	RET (0.77)	RETRIPK2SRCABL1KDM4E
SCHEMBL19763994	0.84	RET (1.00)	RETRIPK2SRCABL1KDM4E
SCHEMBL727933	0.81	RET (0.62)	RETRIPK2SRCABL1EGFR
SCHEMBL10098363	0.80	RET (0.61)	RETRIPK2SRCABL1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012003544-A1	PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU)	2012-01-12	—	—	WO	disclosed