Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.55 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 4/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | GBA2 | Q9HCG7 | 8/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23865736 | 1.00 | SPHK2 (0.58) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL23866033 | 1.00 | SPHK2 (0.58) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL11194154 | 0.98 | SPHK2 (0.61) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL11195122 | 0.98 | SPHK2 (0.61) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL6600533 | 0.98 | SPHK2 (0.61) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL11206595 | 0.98 | SPHK2 (0.61) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL7367083 | 0.95 | SPHK2 (0.56) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL23777202 | 0.95 | SPHK2 (0.56) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL20330675 | 0.95 | SPHK2 (0.64) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL4383140 | 0.95 | SPHK2 (0.64) | SPHK2SPHK1S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608723-B2 | N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-1H-benzimidazol-2-yl)-2-methylpropyl]-4-chlorobenzamide;kinesin spindle protein modulators; anticarcinogenic agents; in vivo stability, bio-availability; diagnosis/medical/;antitumor agents hyperplasia; restinosis; antiinflammatory agents; cardiac hypertrophy | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-10-27 | — | — | US | disclosed |
| EP-0429984-B1 | Indole derivatives | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5124324-A | Psychological disorders, 5-hydroxy tryptamine antagonists | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-06-23 | — | — | US | disclosed |
| EP-0429984-A2 | Indole derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |
| US-4260623-A | Hexahydro-1-arylspiro(3H-oxazolo(3,4-A)pyridine-3,4'-piperidene) antidepressants, pharmaceutical compositions thereof and method of use thereof | WARNER-LAMBERT COMPANY (US) | 1981-04-07 | — | — | US | disclosed |