Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | TTK | P33981 | 1/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.66 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27892862 | 0.84 | MAPT (0.65) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL7281860 | 0.79 | AURKA (0.66) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL2684595 | 0.79 | AURKA (1.00) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL18666770 | 0.79 | MAPT (0.43) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL14934094 | 0.77 | PDGFRB (0.49) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL11229832 | 0.76 | PDGFRB (0.56) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL7271245 | 0.76 | AURKA (0.60) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL5781823 | 0.76 | AURKA (0.60) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL5780302 | 0.76 | AURKA (0.60) | AURKATTKAURKBINCENPPDGFRB | |
| SCHEMBL5778713 | 0.73 | AXL (0.60) | AURKATTKAURKBINCENPPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109027-A1 | Pyridine derivatives, process for their preparation and composition containing them | STERLING DRUG INC. (US) | 1984-05-23 | — | — | EP | disclosed |