Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | METAP1 | P53582 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272150 | 1.00 | MAOB (0.52) | MAOBMETAP1CYP19A1MAPK14NPC1 | |
| SCHEMBL18746297 | 0.89 | MAPT (0.53) | METAP1CYP19A1MAPK14NPC1RAB9A | |
| SCHEMBL10458884 | 0.89 | MAPT (0.53) | METAP1CYP19A1MAPK14NPC1RAB9A | |
| SCHEMBL356453 | 0.87 | MAPT (0.51) | MAOBCYP19A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL356454 | 0.87 | MAPT (0.51) | MAOBCYP19A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31147657 | 0.87 | MAPT (0.51) | MAOBCYP19A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31167959 | 0.87 | MAPT (0.51) | MAOBCYP19A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5969900 | 0.87 | MAPT (0.51) | MAOBCYP19A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19330671 | 0.86 | METAP1 (0.51) | MAOBMETAP1CYP19A1MAPK14NPC1 | |
| SCHEMBL19330670 | 0.86 | METAP1 (0.51) | MAOBMETAP1CYP19A1MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0179855-B1 | DOPAMINE AGONISTS | Whitby Research Incorporated (US) | 1992-07-29 | — | — | EP | disclosed |
| EP-0179855-A4 | DOPAMINE AGONISTS. | NELSON RES & DEV COMPANY (US) | 1986-08-21 | — | — | EP | disclosed |
| EP-0179855-A1 | DOPAMINE AGONISTS. | NELSON RES & DEV (US) | 1986-05-07 | — | — | EP | disclosed |
| WO-1985004582-A1 | NOVEL DOPAMINE AGONISTS | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1985-10-24 | — | — | WO | disclosed |
| US-4540691-A | Dopamine agonists and use thereof | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1985-09-10 | — | — | US | disclosed |
| US-4420480-A | PARKINSONISM, DEPRESSION, HYPOTENSIVES | MERCK & CO., INC. (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0080115-A2 | Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them | MERCK & CO. INC. (US) | 1983-06-01 | — | — | EP | disclosed |