Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.67 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278277 | 0.85 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7272381 | 0.85 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7278758 | 0.84 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7271411 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7278448 | 0.75 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7278478 | 0.75 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| Hydrochloric Acid SCHEMBL7282373 | 0.74 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL2457079 | 0.73 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL9432250 | 0.72 | NPSR1 (0.49) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| Hydrochloric Acid SCHEMBL7272343 | 0.72 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459505-B1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5468756-A | Antiinflammatory, antiallergen | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |