Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7272797 | 0.99 | PDE5A (0.56) | PDE5APOLBSMN1; SMN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10847315 | 0.99 | PDE5A (0.56) | PDE5APOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10869519 | 0.88 | PDE5A (0.59) | PDE5APOLBSMN1; SMN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10963683 | 0.87 | PDE5A (0.60) | PDE5APOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7281035 | 0.85 | PDE5A (0.55) | PDE5ASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL7270959 | 0.85 | PDE2A (0.58) | PDE5ASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL7270925 | 0.85 | PDE5A (0.56) | PDE5APOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10650662 | 0.84 | PDE5A (0.49) | PDE5APOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10961392 | 0.84 | PDE5A (0.49) | PDE5ASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL10415615 | 0.84 | PDE5A (0.57) | PDE5AKDM4EALDH1A1HPGDPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| US-4603139-A | 2-PHENYL-1H-IMIDAZOL(4,5-C)PYRIDINES, ANTICXOAGULANTS, CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. | 1986-07-29 | — | — | US | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |
| EP-0079083-A1 | New imidazo[4,5-c]pyridine derivatives, processes for their preparation and pharmaceutical formulations containing such compounds | MERCK PATENT GmbH (DE) | 1983-05-18 | — | — | EP | disclosed |