Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7280517 | 0.98 | LRRK2 (0.39) | LRRK2NMT1HRH3MAOAMAOB | |
| SCHEMBL7272083 | 0.84 | LRRK2 (0.41) | LRRK2NMT1HRH3MAOAMAOB | |
| Hydrochloric Acid SCHEMBL7273405 | 0.83 | LRRK2 (0.40) | LRRK2NMT1HRH3MAOAMAOB | |
| SCHEMBL7282429 | 0.81 | LRRK2 (0.34) | LRRK2NMT1HRH3NSD2SLC5A7 | |
| SCHEMBL7281975 | 0.81 | SLC5A7 (0.37) | LRRK2NMT1HRH3NSD2SLC5A7 | |
| Hydrochloric Acid SCHEMBL7281306 | 0.80 | SMN1; SMN2 (0.35) | LRRK2NMT1HRH3NSD2SLC5A7 | |
| Hydrochloric Acid SCHEMBL7279544 | 0.80 | SLC5A7 (0.37) | LRRK2NMT1HRH3NSD2SLC5A7 | |
| SCHEMBL7272297 | 0.76 | SMN1; SMN2 (0.41) | LRRK2HRH3SMN1; SMN2HRH4CHRM2 | |
| Hydrochloric Acid SCHEMBL7271450 | 0.76 | SMN1; SMN2 (0.43) | LRRK2HRH3SMN1; SMN2HRH4CHRM2 | |
| SCHEMBL7272217 | 0.73 | LRRK2 (0.40) | LRRK2HRH3MAOAMAOBNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643923-A | TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0456519-B1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| EP-0456519-A1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1991-11-13 | — | — | EP | disclosed |