Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7281773 | 0.98 | LRRK2 (0.39) | LRRK2MAOAMAOBCSF1RHRH3 | |
| SCHEMBL19575602 | 0.92 | CNR2 (0.39) | CSF1RIGF1RCHRM2CHRM4CHRM5 | |
| SCHEMBL21004233 | 0.83 | HRH3 (0.43) | HRH3CYP2D6 | |
| SCHEMBL21004234 | 0.83 | CSF1R (0.39) | CSF1RHRH3CYP2D6CHRM2CHRM4 | |
| SCHEMBL7278456 | 0.81 | IGF1R (0.40) | LRRK2MAOAMAOBHRH3IGF1R | |
| Hydrochloric Acid SCHEMBL7278665 | 0.80 | IGF1R (0.40) | LRRK2HRH3SMN1; SMN2IGF1R | |
| SCHEMBL7281453 | 0.80 | SLC5A7 (0.41) | LRRK2MAOAMAOBHRH3TDO2 | |
| SCHEMBL21525596 | 0.80 | CYP2D6 (0.43) | CSF1RHRH3CYP2D6 | |
| Hydrochloric Acid SCHEMBL7271079 | 0.79 | SLC5A7 (0.41) | HRH3SMN1; SMN2IGF1RCHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL7272888 | 0.77 | HRH1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643923-A | TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0456519-B1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| EP-0456519-A1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1991-11-13 | — | — | EP | disclosed |